Acetic Acid → HCID 18455218, compound

HRID 1271841Notes

Reaction equation

HRID 1271841 reaction equation
C(O)(=O)C.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[O:15][CH2:16][CH2:17][C:18]1[S:22][CH:21]=[N:20][C:19]=1[CH3:23])[CH:10]=O.[CH2:24]1[CH2:31][CH:30]([NH2:32])[C:28](=[O:29])[NH:27][CH2:26][CH2:25]1>CO>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][C:14]=1[O:15][CH2:16][CH2:17][C:18]1[S:22][CH:21]=[N:20][C:19]=1[CH3:23])[CH2:10][NH:32][CH:30]1[CH2:31][CH2:24][CH2:25][CH2:26][NH:27][C:28]1=[O:29]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1024632H-Azepin-2-one, 3-aminohexahydro-HCID 184552233-Methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzaldehyde

Product 1

HCID 18455218HCID 18455218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Acetic acid (9.4 mmol) was added to 3-Methoxy-4-[2-(4-methyl-thiazol-5-yl)-ethoxy]-benzaldehyde (6) (2.3 mmol) and DL-α-amino-ε-caprolactam (2.3 mmol) in minimal amount of methanol and stirred for 2 h. MeOH (0.2 M) was added followed by NaH3BCN (2.3 mmol), and the reaction was stirred for 19 h. The product (7) was obtained by purification upon reverse phase HPLC.

Workup

  1. stirringthe reaction was stirred for 19 h

Sources & evidence

ORD record
ord-6dba1e30e5cc4c3fa38746d12e9a111d
Source dataset
uspto-grants-2007_04
Patent number
US07208488B2

Reaction notes

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