tert-butyl N-(2-oxoethyl)carbamate → HCID 10457279, compound

HRID 1271887Notes

Reaction equation

HRID 1271887 reaction equation
C(OC(=O)NCCNC([C:15]1[N:24]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:23](=[O:32])[C:22]2[C:17](=[CH:18][C:19]([Cl:33])=[CH:20][CH:21]=2)[N:16]=1)C(C)C)(C)(C)C.N[CH:36]([C:40]1[N:49]([CH2:50][C:51]2[CH:56]=CC=C[CH:52]=2)[C:48](=[O:57])[C:47]2[C:42](=CC(Cl)=C[CH:46]=2)[N:41]=1)C(C)C.[C:59](OC(=O)NCC=O)(C)(C)C.C(O[BH3-])(=O)C.[Na+]>>[CH2:25]([N:24]1[C:23](=[O:32])[C:22]2[C:17](=[CH:18][C:19]([Cl:33])=[CH:20][CH:21]=2)[N:16]=[C:15]1[CH:50]([N:49]1[C:48](=[O:57])[C:47]([CH3:46])([CH3:59])[CH2:42][NH:41][CH2:36][CH2:40]1)[CH:51]([CH3:52])[CH3:56])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 4

HCID 4247255tert-butyl N-(2-oxoethyl)carbamateHCID 18455022HCID 18455022, compoundHCID 222387982-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-oneHCID 23670382Sodiumacetoxyborohydride

Product 1

HCID 10457279HCID 10457279, compound

Procedure

Preparation of {2-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-2-methyl-propylamino]-ethyl}-carbamic acid tert-butyl ester: Following the procedure of Example 1b, 2-(1-amino-2-methyl-propyl)-3-benzyl-7-chloro-3H-quinazolin-4-one, (2-oxo-ethyl)-carbamic tert-butyl ester and sodium acetoxyborohydride gave the title compound as a white solid: MS (ES) m/e 485.2 (M+H)+.

Sources & evidence

ORD record
ord-6fbdb1973f204f9394df66f294b06d42
Source dataset
uspto-grants-2007_04
Patent number
US07208487B2

Reaction notes

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