Hydrochloric Acid → HCID 178478615, compound

HRID 127200Notes

Reaction equation

HRID 127200 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]1[NH:16][C:15](=[O:17])[C:14]([CH2:18][C:19]2[CH:20]=[N:21][C:22]([O:25]C)=[CH:23][CH:24]=2)=[CH:13][N:12]=1.[ClH:27]>C(O)C>[ClH:27].[ClH:27].[ClH:27].[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]1[NH:16][C:15](=[O:17])[C:14]([CH2:18][C:19]2[CH:20]=[N:21][C:22]([OH:25])=[CH:23][CH:24]=2)=[CH:13][N:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 127995592-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone

Product 1

HCID 178478615HCID 178478615, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone in 2N hydrogen chloride in ethanol was boiled under reflux for 24 hours. The mixture was evaporated to dryness and the residue was recrystallised from 2-propanol/ethanol containing hydrogen chloride to give 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(6-hydroxy-3-pyridylmethyl)-4-pyrimidone trihydrochloride, m.p. 200-204°.

Workup

  1. temperatureunder reflux for 24 hours
  2. customThe mixture was evaporated to dryness
  3. customthe residue was recrystallised from 2-propanol/ethanol
  4. additioncontaining hydrogen chloride

Sources & evidence

ORD record
ord-e78fff0687c14b079aab589705b4bcc9
Source dataset
uspto-grants-1981_03
Patent number
US04255428

Reaction notes

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