Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(2-Chloro-4-hydroxy-phenyl)-N-methyl-acetamide → 2-{2-Chloro-4-[2-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-phenyl}-N-methyl-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(2-Chloro-4-hydroxy-phenyl)-N-methyl-acetamide | HCID 18456578 | — |
| 반응물 | (7-Chloro-thieno[3,2-b]pyridin-2-yl)-(3-hydroxy-pyrrolidin-1-yl)-methanone | HCID 22143479 | — |
| 생성물 | 2-{2-Chloro-4-[2-((R)-3-hydroxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-phenyl}-N-methyl-acetamide | HCID 58847460 | — |
반응 단계
was prepared from coupling of (7-chloro-thieno[3,2-b]pyridin-2-yl)-(3-hydroxy-pyrrolidin-1-yl)-methanone (2b) with intermediate 63a following Method C. 1H NMR (300 MHz, CD3OD) δ 8.45 (d, 1H, J=5.47 Hz), 7.84 (d, 1H, J=17.33 Hz), 7.40 (d, 1H, J=8.48 Hz), 7.29 (d, 1H, J=2.26 Hz), 7.13–7.08 (m, 1H), 6.74 (d, 1H, J=5.46 Hz), 4.42 (bs, 1H), 4.03–3.90 (m, 2H), 3.74–3.58(m, 5H), 2.66 (s, 3H), 2.10–1.97(m, 2H). LCMS (ESI+) [M+H]/z Calc'd 446, found 446. Anal. (C21H20N3O4SCl.0.7CH2Cl2), C, H, N.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07208500B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-49883559922f40c09e87eb6fc8e3ef55 |
| 출처 메모 | uspto-grants-2007_04 |