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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 127206Generated: October 25, 2026

Ethanol → 2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone

https://huagongshe.com/reaction/127206

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolHCID 702—
Reactant4-(((2-Aminoethyl)thio)methyl)-5-methylimidazoleHCID 665568—
Reactant2-Nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 12783834—
SolventIsopropanolHCID 3776—
Product2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidoneHCID 12788678—

Reaction Steps

Reaction of 2-nitroamino-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone with 1.06 molar equivalents of 2-(5-methyl-4-imidazolylmethylthio)ethylamine in refluxing ethanol for 24 hours gave 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone, m.p. 128-130° (from 2-propanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04255428
Source datasetuspto-grants-1981_03
ORD IDord-06d75e9eee97420e980a2f62bef5b330
Source noteuspto-grants-1981_03