2-Aminopyridine → Acetic acid (4-methoxy-phenyl)-(pyridin-2-ylcarbamoyl)-methyl ester

HRID 1272069Notes

Reaction equation

HRID 1272069 reaction equation
[C:1]([O:4][CH:5]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)[C:6]([OH:8])=O)(=[O:3])[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1>>[CH3:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([CH:5]([O:4][C:1](=[O:3])[CH3:2])[C:6](=[O:8])[NH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 18456650Acetoxy-(4-methoxy-phenyl)-acetic acid

Product 1

HCID 58847454Acetic acid (4-methoxy-phenyl)-(pyridin-2-ylcarbamoyl)-methyl ester

Procedure

was prepared from intermediate 79a and 2-aminopyridine following Method A. 1H NMR (300 MHz, CDCl3) δ 9.06 (s, 1H), 8.31–8.23 (m, 2H), 7.81–7.75 (m, 1H), 7.43 (d, 2H, J=8.59 Hz), 6.90 (d, 2H, J=8.59 Hz), 6.14 (s, 1H), 3.79 (s, 3H), 2.25 (s, 3H). LCMS (ESI+) [M+H]/z Calc'd 301, found 301.

Sources & evidence

ORD record
ord-fd9e861b76b74a6f8af44b1dfaa4e571
Source dataset
uspto-grants-2007_04
Patent number
US07208500B2

Reaction notes

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