反应详情

A mixture of 2-[2-(5-methyl-4-imidazolylmethylthio) ethylamino]-5-(4-methoxy-2-pyridylmethyl)-4-pyrimidone (0.97 g) and aqueous hydrobromic acid (48%, 20 ml) was boiled under reflux for 20 hours and evaporated to dryness. The residue was recrystallised from a mixture of ethanol and 2-propanol to give 2-]2-(5-methyl-4-imidazolylmethylthio) ethylamino]-5-(4-hydroxy-2-pyridylmethyl)-4-pyrimidone trihydrobromide, m.p. 167-169°. On recrystallisation from a mixture of ethanol and 2-propanol the melting point of the sample was lower owing to loss of hydrogen bromide.

1. temperatureunder reflux for 20 hours
2. customevaporated to dryness
3. customThe residue was recrystallised from a mixture of ethanol and 2-propanol