5-(2-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione → 3-[5-(2-Chloro-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

Participants

Reaction Conditions

Reaction Steps

5-(2-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep96, 150 mg, 0.46 mmol) was dissolved in THF (5.6 ml) and 1N HClaq (0.46 ml) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (0.067 ml, 0.48 mmol) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

Provenance & Evidence