反应详情

温度

40 °C

5-(2-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep96, 150 mg, 0.46 mmol) was dissolved in THF (5.6 ml) and 1N HClaq (0.46 ml) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (0.067 ml, 0.48 mmol) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

1. addition1N HClaq (0.46 ml) was added
2. customthe solvent was carefully removed in vacuum at room temperature
3. customdried
4. customto give a white powder that
5. customwas used in the next step without further purification (quantitative yield)