Trifluoroacetic acid → (4R,9aR)-6-Chloro-7-ethoxy-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene

HRID 1272103Notes

Reaction equation

C(OC([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15]([Cl:22])=[C:14]([O:23][CH2:24][CH3:25])[CH:13]=3)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>>[Cl:22][C:15]1[N:16]=[C:17]2[C:12](=[CH:13][C:14]=1[O:23][CH2:24][CH3:25])[CH2:11][C@H:10]1[N:18]2[C@H:19]([CH3:21])[CH2:20][NH:8][CH2:9]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86596344(4R,9aR)-6-chloro-7-ethoxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

Product 1

HCID 86596343(4R,9aR)-6-Chloro-7-ethoxy-4-methyl-1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene

Procedure

This compound was prepared in analogy to Example 1 from (4R,9aR)-6-chloro-7-ethoxy-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester and trifluoroacetic acid.

Sources & evidence

ORD record: ord-2c99dc1ef3484b2d988a90554549a03a
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07208494B2

Reaction notes

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