Hydrochloric Acid → HCID 18455936, compound

HRID 1272184Notes

Reaction equation

HRID 1272184 reaction equation
C(OC([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][CH:15]=[C:14]([F:22])[C:13]=3[CH2:23][OH:24])[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[F:22][C:14]1[C:13]([CH2:23][OH:24])=[C:12]2[C:17]([N:18]3[C@H:10]([CH2:11]2)[CH2:9][NH:8][CH2:20][C@H:19]3[CH3:21])=[N:16][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11667216HCID 11667216, compound

Product 1

HCID 18455936HCID 18455936, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 0.040 g (4R,9aR)-7-fluoro-8-hydroxymethyl-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester in 1 mL of a 2M solution of hydrochloric acid in dioxane was kept at room temperature for 18 h. The solvents were evaporated and the residue was purified by chromatography on silica gel with dichloromethane:methanol:ammonia (25% in water ) (9:1:0.1). The product fractions were collected and evaporated to yield 0.0215 g of yellowish foam.

Workup

  1. customThe solvents were evaporated
  2. customthe residue was purified by chromatography on silica gel with dichloromethane
  3. customThe product fractions were collected
  4. customevaporated

Sources & evidence

ORD record
ord-76aabe3365fb4b1cafd3448c4e092546
Source dataset
uspto-grants-2007_04
Patent number
US07208494B2

Reaction notes

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