反应详情

To acetic anhydride (5 ml) was added 3-(4-fluorophenyl)glutaric acid (2.00 g, 8.84 mmol) and the mixture was refluxed for 3 hours. The resulting mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate-hexane to obtain 1.4 g (yield 76%) of the title compound. mp. 99–104° C.

1. temperaturethe mixture was refluxed for 3 hours
2. concentrationThe resulting mixture was concentrated under reduced pressure
3. customthe residue was crystallized from ethyl acetate-hexane