Acetic Anhydride → 4-(4-fluorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Participants

Reaction Steps

To acetic anhydride (5 ml) was added 3-(4-fluorophenyl)glutaric acid (2.00 g, 8.84 mmol) and the mixture was refluxed for 3 hours. The resulting mixture was concentrated under reduced pressure, and the residue was crystallized from ethyl acetate-hexane to obtain 1.4 g (yield 76%) of the title compound. mp. 99–104° C.

Provenance & Evidence