HCID 10117664, compound → HCID 10140045, compound

HRID 1272290Notes

Reaction equation

HRID 1272290 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][C:13](=O)[N:12]([C:16]3[C:17]([CH3:36])=[C:18]([CH3:35])[C:19]4[O:23][C:22]([CH3:25])([CH3:24])[C@H:21]([C:26]5[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=5)[C:20]=4[C:33]=3[CH3:34])[C:11](=O)[CH2:10]2)=[CH:5][CH:4]=1>C(OCC)(=O)C.CCCCCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:10][CH2:11][N:12]([C:16]3[C:17]([CH3:36])=[C:18]([CH3:35])[C:19]4[O:23][C:22]([CH3:25])([CH3:24])[C@H:21]([C:26]5[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=5)[C:20]=4[C:33]=3[CH3:34])[CH2:13][CH2:14]2)=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 10117664HCID 10117664, compound

Product 1

HCID 10140045HCID 10140045, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using (3R)-4-(4-methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl)piperidine-2,6-dione obtained in Example 26, the title compound was synthesized in the same manner as in Example 28. Yield 59%. mp. 183–185° C. (ethyl acetate-hexane).

Sources & evidence

ORD record
ord-efef7231244641e38ab9ad80d9425f8c
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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