Piperidine → HCID 10205053, compound

HRID 1272308Notes

Reaction equation

HRID 1272308 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[C:22]([CH3:35])=[C:23]([CH3:34])[C:24]4[O:28][C:27]([CH3:30])([CH3:29])[CH:26](O)[C:25]=4[C:32]=3[CH3:33])[CH2:17][CH2:16]2)=[CH:11][CH:10]=1>>[CH3:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[C:22]([CH3:35])=[C:23]([CH3:34])[C:24]4[O:28][C:27]([CH3:29])([CH3:30])[CH:26]([N:1]5[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]5)[C:25]=4[C:32]=3[CH3:33])[CH2:17][CH2:16]2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 674202085-(4-(4-Methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

Product 1

HCID 10205053HCID 10205053, compoundYield 80%

Procedure

Using piperidine and 5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 18, the title compound was synthesized in the same manner as in Example 57. Yield 80%.

Workup

  1. customobtained in Reference Example 18

Sources & evidence

ORD record
ord-436d248b8b9d49708addd90b851dc3c7
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

Loading…