HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylpiperidine → 4-(4-Methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-3-(4-phenylpiperidino)-2,3-dihydro-1-benzofuran-5-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 5-(4-(4-Methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol | HCID 67420208 | — |
| Product | 4-(4-Methoxyphenyl)-1-(2,2,4,6,7-pentamethyl-3-(4-phenylpiperidino)-2,3-dihydro-1-benzofuran-5-yl)piperazine | HCID 10187155 | 45% |
Reaction Steps
Using 4-phenylpiperidine and 5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 18, the title compound was synthesized in the same manner as in Example 57. Yield 45%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208495B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-81276deef4954faf858b152c1b122cf6 |
| Source note | uspto-grants-2007_04 |