HRID1272309

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69873

4-Phenylpiperidine

C11H15N

结构：COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(O)C(C)(C)O4)CC2)cc1

HCID67420208

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(N2CCN(c3c(C)c(C)c4c(c3C)C(N3CCC(c5ccccc5)CC3)C(C)(C)O4)CC2)cc1

HCID10187155

未命名化合物

收率 45%

PROCEDURE

实验过程

Using 4-phenylpiperidine and 5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 18, the title compound was synthesized in the same manner as in Example 57. Yield 45%.

WORKUP

后处理

customobtained in Reference Example 18

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-81276deef4954faf858b152c1b122cf6
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07208495B2
来源说明: uspto-grants-2007_04

反应 SMILES

[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:27]3[C:28]([CH3:41])=[C:29]([CH3:40])[C:30]4[O:34][C:33]([CH3:36])([CH3:35])[CH:32](O)[C:31]=4[C:38]=3[CH3:39])[CH2:23][CH2:22]2)=[CH:17][CH:16]=1>>[CH3:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:27]3[C:28]([CH3:41])=[C:29]([CH3:40])[C:30]4[O:34][C:33]([CH3:35])([CH3:36])[CH:32]([N:10]5[CH2:9][CH2:8][CH:7]([C:1]6[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=6)[CH2:12][CH2:11]5)[C:31]=4[C:38]=3[CH3:39])[CH2:23][CH2:22]2)=[CH:19][CH:20]=1