3-(4-Methoxyphenyl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol → 4-(4-Methoxyphenyl)-1-(3-(4-methoxyphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

HRID 1272317Notes

Reaction equation

HRID 1272317 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2(O)[C:13]3[C:14]([CH3:34])=[C:15]([N:20]4[CH2:25][CH2:24][N:23]([C:26]5[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=5)[CH2:22][CH2:21]4)[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]=3[O:11][C:10]2([CH3:36])[CH3:35])=[CH:5][CH:4]=1>C(O)C>[CH3:33][O:32][C:29]1[CH:30]=[CH:31][C:26]([N:23]2[CH2:22][CH2:21][N:20]([C:15]3[C:16]([CH3:19])=[C:17]([CH3:18])[C:12]4[O:11][C:10]([CH3:36])([CH3:35])[CH:9]([C:6]5[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=5)[C:13]=4[C:14]=3[CH3:34])[CH2:25][CH2:24]2)=[CH:27][CH:28]=1

Participants

3

Reactant 1

HCID 588473523-(4-Methoxyphenyl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

Product 1

HCID 184560734-(4-Methoxyphenyl)-1-(3-(4-methoxyphenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazineYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using 3-(4-methoxyphenyl)-5-(4-(4-methoxyphenyl)piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Example 66, the title compound was synthesized in the same manner as in Example 46. Yield 88%. mp. 205–207° C. (ethanol).

Sources & evidence

ORD record
ord-83fa6f00ddba4885b19ddbc3e15ddf7f
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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