2,3,4,5-Tetrahydro-1H-benzo(d)azepine → 3-(5-(4-[3,4-dimethoxyphenyl]piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl)-2,3,4,5-tetrahydro-1H-3-benzoazepin

HRID 1272330노트

반응식

HRID 1272330 반응식
[CH2:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][NH:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[C:29]([CH3:42])=[C:30]([CH3:41])[C:31]4[O:35][C:34]([CH3:37])([CH3:36])[CH:33](O)[C:32]=4[C:39]=3[CH3:40])[CH2:24][CH2:23]2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>CCCCCC.CO>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:22]2[CH2:23][CH2:24][N:25]([C:28]3[C:29]([CH3:42])=[C:30]([CH3:41])[C:31]4[O:35][C:34]([CH3:36])([CH3:37])[CH:33]([N:3]5[CH2:2][CH2:1][C:7]6[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=6[CH2:5][CH2:4]5)[C:32]=4[C:39]=3[CH3:40])[CH2:26][CH2:27]2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]

참가 물질

4

반응물 2

HCID 14002432,3,4,5-Tetrahydro-1H-benzo(d)azepineHCID 674206985-(4-(3,4-Dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol

생성물 1

HCID 102095953-(5-(4-[3,4-dimethoxyphenyl]piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl)-2,3,4,5-tetrahydro-1H-3-benzoazepin수율 54%

시약·촉매·용매 1

HCID 21896459Hexane methanol용매

실험 절차

Using 2,3,4,5-tetrahydro-1H-3-benzazepine and 5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 19, the title compound was synthesized in the same manner as in Example 57. Yield 54%. mp. 136–138° C. (hexane-methanol).

후처리

  1. customobtained in Reference Example 19

출처 및 근거

ORD 기록
ord-f88a5c4c28014faf8b4891d615537cca
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208495B2

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