HRID1272330

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1400243

2,3,4,5-Tetrahydro-1H-benzo[d]azepine

C10H13N

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(O)C(C)(C)O4)CC2)cc1OC

HCID67420698

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2CCN(c3c(C)c(C)c4c(c3C)C(N3CCc5ccccc5CC3)C(C)(C)O4)CC2)cc1OC

HCID10209595

未命名化合物

收率 54%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21896459

未命名化合物

PROCEDURE

实验过程

Using 2,3,4,5-tetrahydro-1H-3-benzazepine and 5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 19, the title compound was synthesized in the same manner as in Example 57. Yield 54%. mp. 136–138° C. (hexane-methanol).

WORKUP

后处理

customobtained in Reference Example 19

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f88a5c4c28014faf8b4891d615537cca
来源数据集: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07208495B2
来源说明: uspto-grants-2007_04

反应 SMILES

[CH2:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][NH:3][CH2:2]1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:22]2[CH2:27][CH2:26][N:25]([C:28]3[C:29]([CH3:42])=[C:30]([CH3:41])[C:31]4[O:35][C:34]([CH3:37])([CH3:36])[CH:33](O)[C:32]=4[C:39]=3[CH3:40])[CH2:24][CH2:23]2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]>CCCCCC.CO>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:22]2[CH2:23][CH2:24][N:25]([C:28]3[C:29]([CH3:42])=[C:30]([CH3:41])[C:31]4[O:35][C:34]([CH3:36])([CH3:37])[CH:33]([N:3]5[CH2:2][CH2:1][C:7]6[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=6[CH2:5][CH2:4]5)[C:32]=4[C:39]=3[CH3:40])[CH2:26][CH2:27]2)[CH:17]=[CH:18][C:19]=1[O:20][CH3:21]