HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3,4,5-Tetrahydro-1H-benzo(d)azepine → 3-(5-(4-[3,4-dimethoxyphenyl]piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl)-2,3,4,5-tetrahydro-1H-3-benzoazepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3,4,5-Tetrahydro-1H-benzo(d)azepine | HCID 1400243 | — |
| Reactant | 5-(4-(3,4-Dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol | HCID 67420698 | — |
| Solvent | Hexane methanol | HCID 21896459 | — |
| Product | 3-(5-(4-[3,4-dimethoxyphenyl]piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-yl)-2,3,4,5-tetrahydro-1H-3-benzoazepin | HCID 10209595 | 54% |
Reaction Steps
Using 2,3,4,5-tetrahydro-1H-3-benzazepine and 5-(4-(3,4-dimethoxyphenyl)piperidino)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 19, the title compound was synthesized in the same manner as in Example 57. Yield 54%. mp. 136–138° C. (hexane-methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208495B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-f88a5c4c28014faf8b4891d615537cca |
| Source note | uspto-grants-2007_04 |