HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 69412257, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Fluorobenzyl chloride | HCID 9602 | — |
| Reactant | HCID 9902690 | HCID 9902690 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 69412257 | HCID 69412257 | 25% |
Reaction Steps
Using 4-fluorobenzyl chloride and (2,2,4,6,7-pentamethyl-3-pyrrolidinyl-2,3-dihydro-1-benzofuran-5-yl)piperazine obtained in Example 134, the free base was obtained in the same manner as in Example 2. The free base was treated with 4N hydrogenchloride in ethyl acetate (10 mL) to obtain the title compound. Yield 25% mp. 227–232° C. (decomposition) (ethanol-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208495B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-287a37f3bb7d439cb61cfcb848336b0d |
| Source note | uspto-grants-2007_04 |