Hydrochloric Acid → HCID 69412257, compound

HRID 1272347Notes

Reaction equation

HRID 1272347 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Cl:7])=[CH:4][CH:3]=1.[CH3:10][C:11]1([CH3:34])[CH:15]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[C:14]2[C:21]([CH3:33])=[C:22]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[C:23]([CH3:26])=[C:24]([CH3:25])[C:13]=2[O:12]1.[ClH:35]>C(OCC)(=O)C>[ClH:7].[ClH:35].[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:30]2[CH2:31][CH2:32][N:27]([C:22]3[C:23]([CH3:26])=[C:24]([CH3:25])[C:13]4[O:12][C:11]([CH3:34])([CH3:10])[CH:15]([N:16]5[CH2:17][CH2:18][CH2:19][CH2:20]5)[C:14]=4[C:21]=3[CH3:33])[CH2:28][CH2:29]2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 96024-Fluorobenzyl chlorideHCID 9902690HCID 9902690, compound

Product 1

HCID 69412257HCID 69412257, compoundYield 25%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using 4-fluorobenzyl chloride and (2,2,4,6,7-pentamethyl-3-pyrrolidinyl-2,3-dihydro-1-benzofuran-5-yl)piperazine obtained in Example 134, the free base was obtained in the same manner as in Example 2. The free base was treated with 4N hydrogenchloride in ethyl acetate (10 mL) to obtain the title compound. Yield 25% mp. 227–232° C. (decomposition) (ethanol-ethyl acetate).

Workup

  1. customthe free base was obtained in the same manner as in Example 2

Sources & evidence

ORD record
ord-287a37f3bb7d439cb61cfcb848336b0d
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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