7-Benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine → 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

HRID 1272374Notes

Reaction equation

HRID 1272374 reaction equation
[Cl:1][C:2]1[C:3]2[CH2:15][CH2:14][N:13](CC3C=CC=CC=3)[CH2:12][C:4]=2[N:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[C:3]2[CH2:15][CH2:14][NH:13][CH2:12][C:4]=2[N:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[N:7]=1

Participants

3

Reactant 1

HCID 184565217-Benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine

Product 1

HCID 665248134-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochlorideYield 189.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

4-Chloro-7-(phenylmethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (262 mg, 0.80 mmol) was debenzylated following a procedure similar to that described in Example 3, Step B. Trituration with ether gave 208 mg (95%) of the title compound as an off-white solid. LC-MS 238.1 (M+1).

Sources & evidence

ORD record
ord-c2a18accca5c40e3826cc3c0645f15de
Source dataset
uspto-grants-2007_04
Patent number
US07208498B2

Reaction notes

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