HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine → 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Benzyl-4-chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine | HCID 18456521 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride | HCID 66524813 | 189.7% |
Reaction Steps
4-Chloro-7-(phenylmethyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine (262 mg, 0.80 mmol) was debenzylated following a procedure similar to that described in Example 3, Step B. Trituration with ether gave 208 mg (95%) of the title compound as an off-white solid. LC-MS 238.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208498B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-c2a18accca5c40e3826cc3c0645f15de |
| Source note | uspto-grants-2007_04 |