Hydrochloric Acid → 2-(Ethylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

HRID 1272382Notes

Reaction equation

HRID 1272382 reaction equation
[CH2:1]([S:3][C:4]1[N:5]=[CH:6][C:7]2[CH2:13][CH2:12][N:11](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH2:10][C:8]=2[N:9]=1)[CH3:2].[ClH:33]>CO.O1CCOCC1>[ClH:33].[CH2:1]([S:3][C:4]1[N:5]=[CH:6][C:7]2[CH2:13][CH2:12][NH:11][CH2:10][C:8]=2[N:9]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 184565152-(Ethylthio)-7-trityl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 184565142-(Ethylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochlorideYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A suspension of 81 mg (0.185 mmol) of trityl compound from Step D in 0.5 mL of methanol was treated with 4 N hydrogen chloride solution in dioxane. The reaction mixture was stirred at ambient temperature for 2 h, then concentrated under nitrogen and then in vacuo. Trituration with ether gave 47 mg (˜100%) of the title compound as a pale yellow solid.

Workup

  1. concentrationconcentrated under nitrogen

Sources & evidence

ORD record
ord-218ea88b9fe14a88a41a38601cda8cb5
Source dataset
uspto-grants-2007_04
Patent number
US07208498B2

Reaction notes

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