1-Chloro-4-(chloromethyl)benzene → 1-(4-Chlorobenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

HRID 127247Notes

Reaction equation

HRID 127247 reaction equation
[OH:1][CH:2]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[Cl:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Cl)=[CH:31][CH:30]=1>>[Cl:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][N:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:5][CH2:6]2)=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 130377901-(2-Hydroxy-3-n-hexadecyloxypropyl)-piperazine

Product 1

HCID 130377931-(4-Chlorobenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

Procedure

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 4-chlorobenzylchloride to form 1-(4-chlorobenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine, mp 237°-239° C.

Sources & evidence

ORD record
ord-cba2737f6dda4ea18c3edc6c3a02b8c9
Source dataset
uspto-grants-1981_03
Patent number
US04255426

Reaction notes

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