Water → HCID 58994183, compound

HRID 12725Notes

Reaction equation

HRID 12725 reaction equation
[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16](OC)[O:17]C)[CH:13]=2)=[CH:6][C:5]([CH3:23])=[CH:4][N:3]=1.O>C1COCC1>[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16]=[O:17])[CH:13]=2)=[CH:6][C:5]([CH3:23])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 962WaterHCID 58994220HCID 58994220, compound

Product 1

HCID 58994183HCID 58994183, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5-(2-Fluoro-5-methyl-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep100, 200 mg, 0.62 mmol) was dissolved in THF (5 ml) and 2N HClaq (1 ml) was added. The solution was stirred at room temperature for 3 hours. The reaction mixture was neutralized with TEA (278 μl, 2 mmol). Water was added and the product extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated to give 150 mg of a colorless oil (88% yield).

Workup

  1. addition2N HClaq (1 ml) was added
  2. extractionthe product extracted with ethyl acetate
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-c41b290591b04c7c85d7d9b874803ac9
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

Loading…