Ethyl Acetate → 4-Cyano-1-(2-hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine

HRID 127253ノート

反応式

HRID 127253 の反応式
[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)#[N:2].O1CC1C[CH:18]([O:34][CH:35]([CH2:51][CH:52]1OC1)CCCCCCCCCCCCCCC)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].C(OCC)(=[O:58])C>C(#N)C>[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:5][N:6]([CH2:52][CH:51]([OH:58])[CH2:35][O:34][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:7][CH2:8]1)#[N:2]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 1811384-Piperidinecarbonitrile, 4-phenyl-HCID 180000852,3-Epoxypropyl-n-hexadecylether

生成物 1

HCID 130378024-Cyano-1-(2-hydroxy-3-n-hexadecyloxypropyl)-4-phenylpiperidine収率 62%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
185 °C

実験手順

4-Cyano-4-phenylpiperidine (1.1 g, 0.0059 mol) and 2,3-epoxypropyl-n-hexadecylether (1.6 g, 0.0056 mol) were combined and heated to 185° C. for 30 minutes. After cooling, ethyl acetate (20 ml) and acetonitrile (20 ml) were added, and the resulting solid was collected by filtration (1.6 g, 62% yield): mp 69°-70° C.; ir (KBr) 2227 cm-1.

後処理

  1. temperatureAfter cooling
  2. filtrationthe resulting solid was collected by filtration (1.6 g, 62% yield)

出典と根拠

ORDレコード
ord-d4528777c5964f608a53f391d902c862
出典データセット
uspto-grants-1981_03
特許番号
US04255426

反応ノート

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