HRID127253

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8857

Ethyl acetate

C4H8O2

HCID181138

4-Piperidinecarbonitrile, 4-phenyl-

C12H14N2

结构：CCCCCCCCCCCCCCCC(CC1CO1)OC(CCCCCCCCCCCCCCC)CC1CO1

HCID18000085

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCOCC(O)CN1CCC(C#N)(c2ccccc2)CC1

HCID13037802

未命名化合物

收率 62%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

CONDITIONS

反应条件

温度: 185 °C

PROCEDURE

实验过程

4-Cyano-4-phenylpiperidine (1.1 g, 0.0059 mol) and 2,3-epoxypropyl-n-hexadecylether (1.6 g, 0.0056 mol) were combined and heated to 185° C. for 30 minutes. After cooling, ethyl acetate (20 ml) and acetonitrile (20 ml) were added, and the resulting solid was collected by filtration (1.6 g, 62% yield): mp 69°-70° C.; ir (KBr) 2227 cm-1.

WORKUP

后处理

temperatureAfter cooling
filtrationthe resulting solid was collected by filtration (1.6 g, 62% yield)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4528777c5964f608a53f391d902c862
来源数据集: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04255426
来源说明: uspto-grants-1981_03

反应 SMILES

[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)#[N:2].O1CC1C[CH:18]([O:34][CH:35]([CH2:51][CH:52]1OC1)CCCCCCCCCCCCCCC)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33].C(OCC)(=[O:58])C>C(#N)C>[C:1]([C:3]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:5][N:6]([CH2:52][CH:51]([OH:58])[CH2:35][O:34][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[CH2:7][CH2:8]1)#[N:2]