Fluticasone → Fluticasone Propionate

Participants

Reaction Steps

The crude fluticasone obtained as above is dissolved in 68 ml 1-butanol at 117–120° C. to get a clear solution (which may be optionally charcoalized and filtered hot), and then gradually cooled to ambient temperature for crystallization. The crystallized product is filtered. washed with 1-butanol (4 ml). Dried at 55–60° C. to obtain pure fluticasone propionate (Yield 3.0 g, purity 99.24%).

Provenance & Evidence