Fluticasone → Fluticasone Propionate

HRID 1272565노트

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HRID 1272565 반응식
[CH3:1][C@H:2]1[C@:19]([OH:25])([C:20]([S:22][CH2:23][F:24])=[O:21])[C@:18]2([CH3:26])[C@H:4]([C@H:5]3[C@:15]([F:28])([C@@H:16]([OH:27])[CH2:17]2)[C@:14]2([CH3:29])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]2)=[O:11])[C@@H:7]([F:30])[CH2:6]3)[CH2:3]1>C(O)CCC>[CH3:8][CH2:9][C:10]([O:25][C@@:19]1([C:20]([S:22][CH2:23][F:24])=[O:21])[C@@:18]2([CH3:26])[CH2:17][C@H:16]([OH:27])[C@:15]3([F:28])[C@:14]4([CH3:29])[C:8](=[CH:9][C:10]([CH:12]=[CH:13]4)=[O:11])[C@@H:7]([F:30])[CH2:6][C@H:5]3[C@@H:4]2[CH2:3][C@H:2]1[CH3:1])=[O:11]

참가 물질

3

반응물 1

HCID 5311101Fluticasone

생성물 1

HCID 444036Fluticasone Propionate

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

The crude fluticasone obtained as above is dissolved in 68 ml 1-butanol at 117–120° C. to get a clear solution (which may be optionally charcoalized and filtered hot), and then gradually cooled to ambient temperature for crystallization. The crystallized product is filtered. washed with 1-butanol (4 ml). Dried at 55–60° C. to obtain pure fluticasone propionate (Yield 3.0 g, purity 99.24%).

후처리

  1. customto get a clear solution (which
  2. filtrationfiltered hot), and
  3. filtrationThe crystallized product is filtered
  4. washwashed with 1-butanol (4 ml)
  5. customDried at 55–60° C.

출처 및 근거

ORD 기록
ord-82778423563d463a83ccc265b3146563
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208613B2

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