反应详情

The crude fluticasone obtained as above is dissolved in 68 ml 1-butanol at 117–120° C. to get a clear solution (which may be optionally charcoalized and filtered hot), and then gradually cooled to ambient temperature for crystallization. The crystallized product is filtered. washed with 1-butanol (4 ml). Dried at 55–60° C. to obtain pure fluticasone propionate (Yield 3.0 g, purity 99.24%).

1. customto get a clear solution (which
2. filtrationfiltered hot), and
3. filtrationThe crystallized product is filtered
4. washwashed with 1-butanol (4 ml)
5. customDried at 55–60° C.