HCID 20286520, compound → HCID 20286537, compound

HRID 127259Notes

Reaction equation

HRID 127259 reaction equation
[CH3:1][C:2]1([CH3:23])[C:6]2([CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)[O:5][C:4](=[O:22])[NH:3]1>[Pd].C(O)C>[CH3:1][C:2]1([CH3:23])[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[O:5][C:4](=[O:22])[NH:3]1

Participants

4

Reactant 1

HCID 20286520HCID 20286520, compound

Product 1

HCID 20286537HCID 20286537, compoundYield 100.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4.54 g 4,4-dimethyl-8-carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one, 75 ml ethanol and 1 g 5% palladium on carbon is hydrogenated at 60 psi and 50° for one hour. Filtration and evaporation affords 2.65 g 4,4-dimethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 238°-240°.

Workup

  1. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-fa909dfbfbfb410cb9ec7d0466b15559
Source dataset
uspto-grants-1981_03
Patent number
US04255432

Reaction notes

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