1-Butanol → HCID 21923091, compound

HRID 1272646Notes

Reaction equation

HRID 1272646 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:4](Cl)[N:3]=1.C(O)CCC.[F:22][C:23]([F:33])([F:32])[O:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[CH:27][CH:26]=1>C(O)(C)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH2:14][CH3:15])[CH2:12][CH3:13])=[C:4]([NH:31][C:28]2[CH:29]=[CH:30][C:25]([O:24][C:23]([F:22])([F:32])[F:33])=[CH:26][CH:27]=2)[N:3]=1

Participants

5

Reactant 3

HCID 2631-ButanolHCID 6008484-(Trifluoromethoxy)anilineHCID 21923086HCID 21923086, compound

Product 1

HCID 21923091HCID 21923091, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

The operation is carried out as in Stage 2 of Example 3 starting from 200 mg of the product obtained in Stage 1 of Example 3 and 4 ml of butanol and using 0.13 ml of 4-(trifluoromethoxy)-benzenamine in place of the benzylamine. The reaction medium is agitated at ambient temperature then taken to a temperature of 80 to 85° C. for 22 hours, left to return to ambient temperature, diluted with 4 ml of isopropanol, left for four hours at a temperature of approximately 0° C., followed by separating, washing with 10 ml of isopropanol and drying at a temperature of approximately 50° C.

Workup

  1. waitleft
  2. customto return to ambient temperature
  3. waitleft for four hours at a temperature of approximately 0° C.
  4. customby separating
  5. washwashing with 10 ml of isopropanol
  6. customdrying at a temperature of approximately 50° C.

Sources & evidence

ORD record
ord-5d6b1c5ff4d942ffbd8984bd1c90871d
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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