HCID 21923012, compound → HCID 18457583, compound

HRID 1272650Notes

Reaction equation

HRID 1272650 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([I:23])[CH:18]=2)[N:3]=1.[NH2:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27][CH2:26]1>>[ClH:1].[ClH:1].[NH2:24][CH:25]1[CH2:30][CH2:29][CH:28]([NH:31][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]([CH3:14])[CH2:12][CH3:13])=[C:4]([NH:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([I:23])[CH:18]=3)[N:3]=2)[CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 21923012HCID 21923012, compoundHCID 178511674HCID 178511674, compound

Product 1

HCID 18457583HCID 18457583, compoundYield 1,240.1%

Procedure

The operation is carried out as in Stage 3 of Example 9 starting from 27.9 mg of the product obtained in Stage 1 above and 720 mg of trans-1,4-diaminocyclohexane. After purification under the same conditions as for Example 9, salification is carried out with 10 ml 1.4N HCl/Ethanol followed by evaporating to dryness. In this way 232 mg of expected product is obtained in the form of crystals.

Workup

  1. customAfter purification under the same conditions as for Example 9, salification
  2. customby evaporating to dryness

Sources & evidence

ORD record
ord-326ddc03bed04cb482d9aca8780823b5
Source dataset
uspto-grants-2007_04
Patent number
US07208598B2

Reaction notes

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