HRID1272689

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C=C(C)c1ccc(C[C@@H](NC(=O)OC(C)(C)C)C(=O)OC)s1

HCID68972732

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@@H](Cc1ccc(C(C)C)s1)NC(=O)OC(C)(C)C

HCID68972328

未命名化合物

收率 95.9%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

8.50 g of 2(R)-tert-butoxycarbonylamino-3-(5-isopropenyl-thiophen-2-yl)-propionic acid methyl ester was treated with Pd/C and H2 gas (1 atm) by the general procedure N to afford 8.20 g of 2(R)-tert-butoxycarbonylamino-3-(5-isopropyl-thiophen-2-yl)-propionic acid methyl ester. This ester was treated with HCl/dioxane (4.0 M) to afford 7.10 g of title compound.