HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68972732, compound → 2(R)-tert-butoxycarbonylamino-3-(5-isopropyl-thiophen-2-yl)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68972732 | HCID 68972732 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 2(R)-tert-butoxycarbonylamino-3-(5-isopropyl-thiophen-2-yl)-propionic acid methyl ester | HCID 68972328 | 95.9% |
Reaction Steps
8.50 g of 2(R)-tert-butoxycarbonylamino-3-(5-isopropenyl-thiophen-2-yl)-propionic acid methyl ester was treated with Pd/C and H2 gas (1 atm) by the general procedure N to afford 8.20 g of 2(R)-tert-butoxycarbonylamino-3-(5-isopropyl-thiophen-2-yl)-propionic acid methyl ester. This ester was treated with HCl/dioxane (4.0 M) to afford 7.10 g of title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07208601B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-37dd18dd44ea4fa791f2e3d4ae280313 |
| Source note | uspto-grants-2007_04 |