HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(2,4-Dimethoxy-pyrimidin-5-yl)-pyridine-2-carbonitrile | HCID 58994232 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-pyridine-2-carbonitrile hydrochloride | HCID 68691592 | 97% |
Reaction Steps
3-(2,4-Dimethoxy-pyrimidin-5-yl)-pyridine-2-carbonitrile (Prep102, 1 g, 4.13 mmol) was dissolved in a solution of 4N HCl in dioxane (20 ml). The mixture was refluxed for 45 minutes. The solvent was removed under vacuum to give 1 g of the title compound (97% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-60811416b8df4b4dbe46a3d4a9ede2b1 |
| Source note | uspto-grants-2010_06 |