HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 8-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | HCID 13016615 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 8-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride | HCID 20286519 | — |
Reaction Steps
To a solution of 2 g 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one in 20 ml i-propyl alcohol is added sufficient 3% methanolic hydrogen chloride to make the solution acid to litmus. Addition of 250 ml diethyl ether followed by filtration affords 1.89 g 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride, mp 249°-254° (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255432 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-32741250efb94149956c807f36eb28ae |
| Source note | uspto-grants-1981_03 |