Hydrochloric Acid → 8-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride

HRID 127270Notes

Reaction equation

HRID 127270 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:22][CH2:21][C:15]3([O:19][C:18](=[O:20])[NH:17][CH2:16]3)[CH2:14][CH2:13]2)=[CH:2]1.[ClH:23].C(OCC)C>C(O)(C)C>[ClH:23].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][C:15]3([O:19][C:18](=[O:20])[NH:17][CH2:16]3)[CH2:21][CH2:22]2)=[CH:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 130166158-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one

Product 1

HCID 202865198-[2-(3-Indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 2 g 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one in 20 ml i-propyl alcohol is added sufficient 3% methanolic hydrogen chloride to make the solution acid to litmus. Addition of 250 ml diethyl ether followed by filtration affords 1.89 g 8-[2-(3-indolyl)ethyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride, mp 249°-254° (d).

Workup

  1. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-32741250efb94149956c807f36eb28ae
Source dataset
uspto-grants-1981_03
Patent number
US04255432

Reaction notes

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