Piperidine → 5-Piperidin-1-yl-1,3,4-thiadiazol-2-amine

HRID 1272717Notes

Reaction equation

HRID 1272717 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[S:9][C:10](Cl)=[N:11][N:12]=1>C(O)C>[NH2:7][C:8]1[S:9][C:10]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:11][N:12]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 3142355-Chloro-1,3,4-thiadiazol-2-amine

Product 1

HCID 15000105-Piperidin-1-yl-1,3,4-thiadiazol-2-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Piperidine (100 μl) was added to a solution of 2-amino-5-chloro-1,3,4-thiadiazole (50 mg) in ethanol (1 ml) and the mixture heated in a sealed vial at 70° C. for 6 hours The ethanol was evaporated from the cooled reaction under vacuum, the residue diluted with water and the solid product filtered off to give 2-amino-5-piperid-1-yl-1,3,4-thiadiazole.

Workup

  1. customwas evaporated from the cooled reaction under vacuum
  2. additionthe residue diluted with water
  3. filtrationthe solid product filtered off

Sources & evidence

ORD record
ord-d25a507e060d4028a335c8ac6b6f0fec
Source dataset
uspto-grants-2007_04
Patent number
US07208629B2

Reaction notes

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