Triethylamine → HCID 178505584, compound

HRID 1272777Notes

Reaction equation

HRID 1272777 reaction equation
Cl.C(O[C:5]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)=[NH:6])C.C(N(CC)CC)C.[C:30]1([CH2:36][C:37]([NH:39][NH2:40])=O)[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[F:22][C:19]1[CH:20]=[CH:21][C:16]([C:10]2[C:9]3[C:13](=[CH:14][CH:15]=[C:7]([C:5]4[NH:6][C:37]([CH2:36][C:30]5[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=5)=[N:39][N:40]=4)[CH:8]=3)[NH:12][N:11]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 70301Benzeneacetic acid, hydrazideHCID 22479739ethoxy[3-(4fluorophenyl)(1H-indazol-5-yl)]methanimine hydrochloride

Product 1

HCID 178505584HCID 178505584, compoundYield 44.1%

Procedure

The procedure described in example 123 using ethoxy[3-(4-fluorophenyl)(1H-indazol-5-yl)]methanimine hydrochloride (200 mg, 0.62 mmol), triethylamine (0.25 mL, 1.86 mmol) and phenyl acetic hydrazide (187 mg, 1.25 mmol) was used to prepare the title compound (101 mg, 44% yield). 1H NMR (DMSO-d6) δ 8.7 (s, 1H), 8.05 (m, 3H), 7.5 (d, 1H), 7.2–7.5 (m, 7H), 4.15 (s, 2H), ES-MS(m/z) 370 [M+1]+.

Sources & evidence

ORD record
ord-233eaf241dfa4634ac5a66cf3260f791
Source dataset
uspto-grants-2007_04
Patent number
US07208513B2

Reaction notes

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