反应详情

温度

130 °C

To neat 4-fluorobenzoyl chloride (50.00 g, 315 mmol) in a flask at 130° C. was added 4-bromoaniline (17.00 g, 100 mmol) in several portions. After it was stirred at 130° C. for 1 hour and the temperature was raised to 190° C., to the reaction mixture was added zinc chloride (11.00 g, 80.7 mmol) in several portions, then it was heated at 220° C. for 22 hours. Once cooled to 180° C., to the mixture was carefully added concentrated sulfuric acid (50 mL), acetic acid (70 mL), water (70 mL), and another portion of sulfuric acid (50 mL). The mixture was heated at 120° C. overnight. It was poured into water (500 mL) and a white solid was precipitated. It was collected by filtration and was dissolved in ethyl acetate and washed with 5% sodium carbonate until pH of the aqueous phase reached 8. The filtrate was basified with sodium carbonate and extracted with ethyl acetate. The combined ethyl acetate layers were dried over magnesium sulfate, filtered, and concentrated. The residue was then purified by chromatography (SiO2, 15–20% ethyl acetate/hexane) to provide the title compound (13.64 g, 46% yield). 1H NMR (CDCI3) δ 7.67 (m, 2H), 7.51 (d, 1H), 7.37 (dd, 1H), 7.14–7.20 (m, 2H), 6.65 (d, 1H), 6.02 (br s, 2H); ES-MS (m/z) 296 [M+3]+, 294 [M+1]+.

1. temperaturethe temperature was raised to 190° C., to the reaction mixture
2. temperatureit was heated at 220° C. for 22 hours
3. temperatureOnce cooled to 180° C., to the mixture
4. temperatureThe mixture was heated at 120° C. overnight
5. customa white solid was precipitated
6. filtrationIt was collected by filtration
7. dissolutionwas dissolved in ethyl acetate
8. washwashed with 5% sodium carbonate until pH of the aqueous phase
9. extractionextracted with ethyl acetate
10. dry with materialThe combined ethyl acetate layers were dried over magnesium sulfate
11. filtrationfiltered
12. concentrationconcentrated
13. customThe residue was then purified by chromatography (SiO2, 15–20% ethyl acetate/hexane)