HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-[1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Chloro-6,7-dimethoxy-4-quinazolinamine | HCID 90235 | — |
| Reactant | 2(-Piperidinyl)-isoindolin-1-one | HCID 20286464 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride | HCID 20556257 | — |
Reaction Steps
By heating in an analogous fashion 2.4 g of 4-amino-2chloro-6,7-dimethoxyquinazoline, 2.2 g of 2(-piperidinyl)-isoindolin-1-one, 2.0 g of anhydrous sodium carbonate and 20 ml of dimethylformamide, the 2-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride is obtained, melting at 288°-289° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255429 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-017ce1c48689426aa768cc03e89ed6ed |
| Source note | uspto-grants-1981_03 |