Sodium Carbonate → 2-[1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride

HRID 127281Notes

Reaction equation

HRID 127281 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.N1([N:23]2[CH2:31][C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[C:24]2=O)CCCCC1.[C:33](=[O:36])([O-])[O-].[Na+].[Na+]>CN(C)C=O>[ClH:16].[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([N:23]2[CH2:31][CH2:30][CH:31]([N:23]3[CH2:24][C:25]4[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=4)[C:33]3=[O:36])[CH2:25][CH2:24]2)[N:3]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 202864642(-Piperidinyl)-isoindolin-1-one

Product 1

HCID 205562572-[1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By heating in an analogous fashion 2.4 g of 4-amino-2chloro-6,7-dimethoxyquinazoline, 2.2 g of 2(-piperidinyl)-isoindolin-1-one, 2.0 g of anhydrous sodium carbonate and 20 ml of dimethylformamide, the 2-[1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-isoindolin-1-one monohydrochloride is obtained, melting at 288°-289° (dec.).

Sources & evidence

ORD record
ord-017ce1c48689426aa768cc03e89ed6ed
Source dataset
uspto-grants-1981_03
Patent number
US04255429

Reaction notes

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