HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminopyridine → 3-Methyl-3-phenyl-1-(4-pyridyl)-pyrrolidin-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminopyridine | HCID 1727 | — |
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 3-Methyl-3-phenyloxolane-2,5-dione | HCID 4962834 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Methyl-3-phenyl-1-(4-pyridyl)-pyrrolidin-2,5-dione | HCID 12822545 | — |
Reaction Steps
The starting material is prepared as follows: The mixture of 68.6 g of 2-methyl-2-phenylsuccinic anhydride, 34 g of 4-aminopyridine and 675 ml of xylene is refluxed on a water separator while stirring for 7 hours. It is cooled to 40°, filtered, cooled to 0° and filtered again. The second residue is recrystallized from isopropanol-hexane, to yield the 3-methyl-3-phenyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 90°-92°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04255429 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-e9a1e971e5c948b295f5b816f0cff078 |
| Source note | uspto-grants-1981_03 |