反应详情

The starting material is prepared as follows: The mixture of 68.6 g of 2-methyl-2-phenylsuccinic anhydride, 34 g of 4-aminopyridine and 675 ml of xylene is refluxed on a water separator while stirring for 7 hours. It is cooled to 40°, filtered, cooled to 0° and filtered again. The second residue is recrystallized from isopropanol-hexane, to yield the 3-methyl-3-phenyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 90°-92°.

1. customThe starting material is prepared
2. temperatureIt is cooled to 40°
3. filtrationfiltered
4. temperaturecooled to 0°
5. filtrationfiltered again
6. customThe second residue is recrystallized from isopropanol-hexane