Hydrochloric Acid → HCID 22480020, compound

HRID 1272850Notes

Reaction equation

HRID 1272850 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[O:19])[CH3:18])[CH:15]=3)[N:10](C3CCCCO3)[N:9]=2)=[CH:4][CH:3]=1.Cl>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](=[O:19])[CH3:18])[CH:15]=3)[NH:10][N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22480112HCID 22480112, compound

Product 1

HCID 22480020HCID 22480020, compoundYield 108.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1-[3-(4-fluorophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazol-5-yl]ethan-1-one (100 mg, 0.30 mmol) in methanol (30 mL) was added 6 N HCl (30 mL). The solution was stirred at room temperature for 4.5 hours when the methanol was removed under vacuo and the solution made basic with saturated Na2CO3. The suspension was then filtered and the product dried to give the title compound (83 mg, 100% yield). 1H NMR (DMSO-d6) δ 8.64 (s, 1H), 8.1 (m, 2H), 7.97 (d, 1H), 7.67 (d, 1H), 7.40 (t, 2H), 2.69 20 (s, 3H); ES-MS (m/z) 255 [M+1]+.

Workup

  1. customwas removed under vacuo
  2. filtrationThe suspension was then filtered
  3. customthe product dried

Sources & evidence

ORD record
ord-d6c8a96f4dde4e819d8b0576a11a44c9
Source dataset
uspto-grants-2007_04
Patent number
US07208513B2

Reaction notes

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