3-Methoxypropionic acid → HCID 69421914, compound

HRID 1272863Notes

Reaction equation

HRID 1272863 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14](C#N)[CH:15]=3)[N:10]([CH:19]3[CH2:24][CH2:23][CH2:22][CH2:21][O:20]3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:25][O:26][CH2:27][CH2:28][C:29]([OH:31])=O.Cl.[CH3:33][N:34](C)CCCN=C=NCC>ClCCl>[C:33]([CH:22]1[CH2:21][O:20][CH:19]([N:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:8]([C:4]3[CH:3]=[C:2]([NH:1][C:29](=[O:31])[CH2:28][CH2:27][O:26][CH3:25])[CH:7]=[CH:6][CH:5]=3)=[N:9]2)[CH2:24][CH2:23]1)#[N:34]

Participants

5

Reactant 3

HCID 1344423-Methoxypropionic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 22480146HCID 22480146, compound

Product 1

HCID 69421914HCID 69421914, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared as described in example 222B using 3-(3-aminophenyl)-1-perhydro-2H-pyran-2-yl-1H-indazole-5-carbonitrile (0.300 g, 0.94 mmol) in dichloromethane (10 mL), 3-methoxypropionic acid (0.097 mL, 1.034 mmol), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.216 g, 1.13 mmol). The product was used without chromatographic purification (0.437 g, quantitative yield): ES-MS (m/z) 405 [M+H]+.

Workup

  1. customThe product was used without chromatographic purification (0.437 g, quantitative yield)

Sources & evidence

ORD record
ord-0863b5a79526404fa4349fb2dda3ca4b
Source dataset
uspto-grants-2007_04
Patent number
US07208513B2

Reaction notes

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