Water → HCID 58994189, compound

HRID 12729Notes

Reaction equation

HRID 12729 reaction equation
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[C:13]([C:18]#[N:19])=[N:14][CH:15]=[CH:16][CH:17]=2)[C:9](=[O:20])[NH:8][C:7]1=[O:21].O>C1COCC1>[O:21]=[C:7]1[NH:8][C:9](=[O:20])[C:10]([C:12]2[C:13]([C:18]#[N:19])=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:11][N:6]1[CH2:5][CH2:4][CH:3]=[O:2]

Participants

4

Reactant 2

HCID 962WaterHCID 58994237HCID 58994237, compound

Product 1

HCID 58994189HCID 58994189, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-[1-(3,3-Dimethoxy-propyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-pyridine-2-carbonitrile (Prep104, 210 mg, 0.66 mmol) was dissolved in THF (5 ml) and 2N HClaq (1 ml) was added. The solution was stirred at room temperature for 2 hours. The reaction mixture was neutralized with TEA. Water was added (1 ml) and the product extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 130 mg of a yellow oil (73% yield)

Workup

  1. addition2N HClaq (1 ml) was added
  2. extractionthe product extracted with ethyl acetate
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. customevaporated

Sources & evidence

ORD record
ord-9ad38bc707b046e69c350290cb8d3501
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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