Water → HCID 20286680, compound

HRID 127299Notes

Reaction equation

HRID 127299 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:7]2[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[F:24].O>C(O)(=O)C>[Br:1][C:12]1[CH:11]=[C:10]2[C:6]([C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])=[C:8]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[NH:9]2)=[CH:5][C:4]=1[Cl:3]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 21829635HCID 21829635, compound

Product 1

HCID 20286680HCID 20286680, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Add 1.0 ml of bromine to 4.6 g of ethyl 5-chloro-3-(2-fluorophenyl)indole-2-carboxylate in 250 ml of glacial acetic acid. Stir for 16 hours at room temperature, add water and collect the precipitate. Ws the precipitate with warm methanol. Collect the dry ethyl 6-bromo-5-chloro-3-(2-fluorophenyl)indole-2-carboxylate, m.p. 193°-194°.

Workup

  1. customcollect the precipitate
  2. customCollect the dry ethyl 6-bromo-5-chloro-3-(2-fluorophenyl)indole-2-carboxylate, m.p. 193°-194°

Sources & evidence

ORD record
ord-53f6f81270b145c990fcf2571f79ce83
Source dataset
uspto-grants-1981_03
Patent number
US04255442

Reaction notes

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