Sodium Carbonate → 5-(2-Chloro-6-methyl-pyridin-3-yl)-2,4-dimethoxy-pyrimidine

関与物質

反応手順

2,4-Dimethoxy-5-iodopyrimidine (957 mg, 3.59 mmol) was dissolved in degassed n-PrOH (18 ml) and then 2-chloro-6-methylpyridine-3-boronic acid (923 mg, 5.39 mmol), Na2CO3 (761 mg, 7.2 mmol), PPh3 (94 mg, 0.35 mmol) and Pd(OAc)2 (40 mg) were added. The suspension was stirred at reflux for 3 hours. The solvent was evaporated under vacuum and the crude was partitioned between water and DCM. The organic phase was dried (Na2SO4) and evaporated to give the title compound that was used without further purification in the next step (quantitative yield).

情報源と証拠